IgA Nephropathy
Disease Overview
IgA Nephropathy (IgAN) is a rare autoimmune disease that affects approximately 30 to 40 out of 100,000 people in the United States. Its prognosis carries a substantial risk of progression to kidney failure, with many affected patients requiring dialysis or transplant for survival. IgAN arises when Immunoglobulin A (IgA) antibodies deposit and accumulate in the kidneys, which can lead to chronic glomerular inflammation and decreased kidney function. IgAN is more common in East Asian and European populations, affects a higher proportion of males, and is most predominant in individuals ages 10 to 40. IgAN is believed to be triggered by a combination of genetic, immunological, and environmental factors.
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Page Contributors:
- Member of the Bruin Beans Health Club | Julianna Cummings, UCLA Undergraduate Student
- CORE Kidney Research Associate | Lewis Simon, MPH, PhD