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Displaying 1 - 20 of 1028

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

This is a Phase III, 2-arm, randomised, open-label, multicentre, global study assessing the efficacy and safety of neoadjuvant Dato-DXd plus durvalumab followed by adjuvant durvalumab with or without chemotherapy compared with neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab with or without chemotherapy in participants with previously untreated TNBC or hormone receptor-low/HER2-negative breast cancer.

Phase: Phase 3
Primary Purpose: Treatment
Gender: All
Age Group: Adults
Contact: Monica Rocha

ChatGPT Assisted Interpretation of ERCP Fluoroscopy Images: A Retrospective Single Center Study

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults, Children
Contact: Sneha Dodaballapur
Investigator:
Sneha Dodaballapur

Clinical Study Protocol for assessment of the diagnostic performance of Careverse FFR in suspected coronary artery disease

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Arshia Mian
Investigator: Arash Bedayat, MD

Artivion AMDS Hybrid Prosthesis Device: HDE

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Jenny Lester

Quality improvement assessment of HippoClinic platform

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults, Children
Contact: HSIANG YEH
Investigator: John M. Stern, MD

FAPI PET for Lung Fibrosis

This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD).

The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in normal and fibrotic lung tissues of patients with interstitial lung disease.

The study will include patients with interstitial lung disease who have or will initiate a new ILD medication OR will undergo tissue biopsy or surgery of the lung.

The study will include 30 patients, the upper limit for PET imaging studies conducted under the Radioactive Drug Research Committee (RDRC) purview.

Participants will be injected with up to 7 mCi of 68-GaFAPi and will undergo one PET/CT scan and one High Resolution CT of the lungs.

The study is sponsored by Ahmanson Translational Theranostic Division at UCLA.

Phase: Early Phase 1
Primary Purpose: Diagnostic
Gender: All
Age Group: Adults
Contact: Nahal Ghanoongooi
Investigator: Arissa Young, MD

single patient IND for 177Lu-Edotreotide (lutetium edotreotide) for patient with unresectable meningioma

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: STEPHANIE LIRA
Open Actively Recruiting

Understanding Decision Regret Among Gynecologic Cancer Patients Treated with HDR Brachytherapy

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Phase: N/A
Age Group: Adults
Contact: Rojine Ariani
Investigator:
Rojine Ariani

Pregnancy in Inflammatory Bowel Disease And Neonatal Outcomes (PIANO): Safety of Emerging Crohn's Therapy During Pregnancy and Lactation

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Xiaoxiao Yin

Decoding Thalamic Function in Medically-Refractory Generalized Epilepsy Using In-Vivo Intracranial Electrocorticography

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults, Children
Contact: Diana Chang
Open Actively Recruiting

A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

A study to determine if BHV-8000 is efficacious, safe and tolerable in adults diagnosed with early Parkinson's disease.

Phase: Phase 2/Phase 3
Primary Purpose: Treatment
Gender: All
Age Group: Adults
Contact: Diane Yang

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

XLMTM (X-linked myotubular myopathy) is a serious genetic muscle condition. It is caused by changes in the MTM1 gene which stops or slows down normal muscle development, causing severe muscle weakness. There is currently no cure for XLMTM. Ongoing care is needed to manage symptoms and prevent further medical problems from this condition.

Recent research shows that individuals with XLMTM often have reduced bile flow which can affect liver and gallbladder health. Bile is a liquid made in the liver that helps digest fat. Ongoing liver health checks may help with the routine care of people with XLMTM.

There is a need to understand liver problems that develop in individuals with XLMTM over time. The main aim of the study is to learn how many boys with XLMTM have new cases of liver problems during the study.

This study is about collecting information only. This is known as an observational study. The individual's doctor decides on treatment, not the study sponsor (Astellas).

In this study, boys under 18 diagnosed with XLMTM will be followed for about 1 year. The health of their liver and gallbladder will be checked about every 6 weeks. This can be done at home, if preferred. A scan called a Fibroscan (also known as transient elastography) will check for signs of scarring in the liver (fibrosis) and the build-up of lipids. It is suggested that each boy will have a Fibroscan when they start the study and another scan when they complete the study.

This study will help understand liver, gallbladder, and bile duct issues in individuals with XLMTM over time. The goal is to improve their care and provide information to use in future clinical studies.

Gender: Male
Age Group: Children
Contact: Michael Yan

Multi-Omics Approaches for the Diagnosis and Risk Stratification of Pulmonary Fibrosis-Associated Pulmonary Hypertension

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Lloyd Liang

Retrospective Analysis of Kenalog Effect in Glaucoma Drainage Device Implantation

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Phase: Phase 1
Age Group: Adults
Contact: Mahshad Rafiee
Investigator: Reza Alizadeh, MD
Open Actively Recruiting

NIH-R21CA303383-Advanced Dual-Nuclei MRI for Differentiation of Recurrent Brain Metastases and Radiation Necrosis

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Phase: Phase 2/Phase 3
Age Group: Adults
Investigator:
JINGWEN YAO
Open Actively Recruiting

Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors

This study, the first clinical trial of AVZO-023, aims to determine the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, maximum tolerated dose, and anti-tumor effects of AVZO-023 in patients with advanced solid tumors. AVZO-023 is an oral medication that inhibits cyclin-dependent kinase 4 (CDK4).

Phase: Phase 1/Phase 2
Primary Purpose: Treatment
Gender: All
Age Group: Adults
Contact: Bhavisha Tailor

Feeding Practices During Therapeutic Hypothermia (TH) for Hypoxic-Ischemic Encephalopathy (HIE) in the UCLA NICU

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Children
Contact: Kalpashri Kesavan
Open Actively Recruiting

Mind-Body Stress Biomarkers and Treatment Response in Metastatic Gynecologic Cancer

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Eliya Shachar
Open Actively Recruiting

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.

Phase: N/A
Primary Purpose: Treatment
Gender: All
Age Group: Adults

A RANDOMIZED CONTROL STUDY TO EVALUATE THE EFFECTIVENESS OF LETERMOVIR PROPHYLAXIS VERSUS CONVENTIONAL THERAPY IN LIVER TRANSPLANT RECIPIENTS.

This study has not yet been registered on ClinicalTrials.gov, which is currently a pre-requisite for display of detailed eligibility criteria.

Age Group: Adults
Contact: Noe Guerrero