Jacobs Lab

Publications

Education

Selected publications (of more than 135) listed below

Full list of publications can be found here Jacobs Google Scholar profile (H-Index 41)  |  Jacobs NCBI bibliography 

  1. Kim SG, Zhao MY, Lam C, Jacobs JP. The Current Landscape of Microbial Biomarkers in Gastrointestinal Disease. Gastroenterology Clinics of North America. 1 December 2025
  2. Yang HJ, Corson M, Aja E, Spartz E, Limketkai BN & Jacobs JP. Protein-Calorie Malnutrition Is Associated with Altered Colonic Mucosal Microbiota in Inflammatory Bowel Disease. Nutrients. 2025 Dec 1
  3. Jacobs JP, Labus JS, Dong TS, Shin AS, UCLA SCORE Group in IBS and Sex Differences, Mayer EA, Chang L. Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner. Clinical Gastroenterology and Hepatology. 2025 Jul 29
  4. Zhang D, Leitman M, Pawar S, Shera S, Hernandez L, Jacobs JP, Dong TS. The Association Between Prevotella copri and Advanced Fibrosis in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease. Nutrients. 2025 Jun 27
  5. Yang HH, Simpson CA, Srivastava M, Bera A, Cappelletti M, Suh JD, Wang MB, Beswick DM, Maxim T, Basak SK, Srivatsan ES, Fischer JL, Jacobs JP, Lee JT. Biodiversity of the Bacterial and Fungal Microbiome and Associated Inflammatory Cytokine Profile in Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2025 May
  6. Yang JC, Lagishetty V, Aja E, Arias-Jayo N, Chang C, Hauer M, Katzka W, Sedighian F, Koletic C, Liang F, Dong TS, Situ J, Troutman R, Buri H, Chute S, Simpson CA, Braun J, Jacob J, Jacobs JP. Biogeographical distribution of gut microbiome composition and function is partially recapitulated by fecal transplantation into germ-free mice. The ISME Journal. 2025 Jan 2
  7. Yang JC, Zhao M, Chernikova D, Arias-Jayo N, Zhou Y, Situ J, Gutta A, Chang C, Liang F, Lagishetty V, Jacobs JP. ZIP8 A391T Crohn's Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation. Dig Dis Sci. 2024 Sep 25
  8. Jacobs JP, Spencer EA, Helnus DS, Yang JC, Lagishetty V, Bongers G, Britton GJ, Gettler K, Reyes-Mercedes P, Hu J, Hart A, Lamousé-Smith E, Wehkamp J, Landers C, Debbas P, Torres J, Colombel JF, Cho J, Peter I, Faith J, Braun J, Dubinsky MC. Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families. Gut. 2024 Aug 9
  9. Shera S, Katzka W, Yang JC, Chang C, Arias-Jayo N, Lagishetty V, Balioukova A, Chen Y, Dutson E, Li Z, Mayer EA, Pisegna JR, Sanmiguel C, Pawar S, Zhang D, Leitman M, Hernandez L, Jacobs JP, Dong TS. Bariatric-induced microbiome changes alter MASLD development in association with changes in the innate immune system. Front Microbiol. 2024 Aug 9
  10. Aja E, Jacobs JP. Mommy's microbes: Gestational diabetes mellitus shapes the maternal and infant gut microbiome. Cell Host Microbe. 2024 Jul 10
  11. Chang C, Louie A, Zhou Y, Gupta R, Liang F, Xanthou G, Ereso J, Koletic C, Yang JC, Sedighian F, Lagishetty V, Arias-Jayo N, Altuwayjiri A, Tohidi R, Navab M, Reddy ST, Sioutas C, Hsiai T, Araujo JA, Jacobs JP. Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid. Int J Mol Sci. 2024 Jun 29
  12. Wiley KS, Gregg AM, Fox MM, Lagishetty, Sandman CA, Jacobs JP, Glynn LM. Contact with caregivers is associated with composition of the inflant gastrointestinal microbiome in the first 6 months of life. American Journal of Biological Anthropology. 2024 April
  13. Ye X, Ghosh S, Shin BC, Ganguly A, Maggiotto L, Jacobs JP, Devaskar SU. Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures. Front Neurosci. 2024 Mar 21
  14. Kim MJ, Kim HN, Jacobs JP, Yang HJ. Combined DNA Methylation and Gastric Microbiome Marker Predicts Helicobacter pylori-Negative Gastric Cancer. Gut Liver. 2024 Mar 21
  15. Chang C, Gupta R, Sedighian F, Louie A, Gonzalez D, Le C, Cho JM, Park SK, Castellanos J, Ting TW, Dong TS, Arias-Jayo N, Lagishetty V, Navab M, Reddy S, Sioutas C, Hsiai T, *Jacobs JP, *Araujo JA. Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models. Environ Res. 2024 Jan 17 *Co-senior authors
  16. Wiley KS, Gregg AM, Fox MM, Lagishetty V, Sandman CA, *Jacobs JP, *Glynn LM. Contact with caregivers is associated with composition of the infant gastrointestinal microbiome in the first 6 months of life. Am J Biol Anthropol. 2023 Oct 7 *Co-senior authors
  17. Caremoli F, Huynh J, Lagishetty V, Markovic D, Braun J, Dong TS, Jacobs JP, Sternini C. Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity. Nutrients. 2023 Sep 25
  18. Jacobs JP, Sauk JS, Ahdoot AI, Liang F, Katzka W, Ryu HJ, Khandadash A, Lagishetty V, Labus JS, Naliboff BD, Mayer EA. Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk. Inflamm Bowel Dis. 2023 Aug 31
  19. Jacobs JP, Lee ML, Rechtman DJ, Sun AK, Autran C, Niklas V. Human milk oligosaccharides modulate the intestinal microbiome of healthy adults. Sci Rep. 2023 Aug 31
  20. Lee JT, Simpson CA, Yang HH, Suh JD, Wang MB, Lagishetty V, Liang F, Jacobs JP. Fungal and Bacterial Microbiome in Sinus Mucosa of Patients with and without Chronic Rhinosinusitis. Laryngoscope. 2023 Aug 22
  21. Yang JC, Troutman R, Buri H, Gutta A, Situ J, Aja E, Jacobs JP. Ileal Dysbiosis Is Associated with Increased Acoustic Startle in the 22q11.2 Microdeletion Mouse Model of Schizophrenia. Nutrients. 2023 Aug 18
  22. Zhao M, Jacobs JP. Fecal matters: Microbial signatures distinguish clinically relevant subtypes of precancerous colorectal polyps. Cell Host Microbe. 2023 May 10
  23. Nguyen AD, Andréasson K, McMahan ZH, Bukiri H, Howlett N, Lagishetty V, Lee SM, Jacobs JP, Volkmann ER. Gastrointestinal tract involvement in systemic sclerosis: The roles of diet and the microbiome. Semin Arthritis Rheum. 2023 Feb 24
  24. Jacobs JP, Lagishetty V, Hauer MC, Labus JS, Dong TS, Toma R, Vuyisich M, Naliboff BD, Lackner JM, Gupta A, Tillisch K, Mayer EA. Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes. Microbiome. 2023 Jan 10
  25. Luu K, Ye JY, Lagishetty V, Liang F, Hauer M, Sedighian F, Kwaan MR, Kazanjian KK, Hecht JR, Lin AY, Jacobs JP. Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer. Nutrients. 2023 Jan 9
  26. Yang JC, Jacobs JP, Hwang M, Sabui S, Liang F, Said HM, Skupsky J. Biotin Deficiency Induces Intestinal Dysbiosis Associated with an Inflammatory Bowel Disease-like Phenotype. Nutrients. 2023 Jan 4
  27. Dong TS, Katzka W, Yang JC, Chang C, Arias-Jayo N, Lagishetty V, Balioukova A, Chen Y, Dutson E, Li Z, Mayer EA, Pisegna JR, Sanmiguel C, Jacobs JP. Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease. Gut Microbes. 2023 Jan-Dec
  28. Maggiotto LV, Ghosh S, Shin BC, Ganguly A, Lagishetty V, Jacobs JP, Devaskar SU. Variation in the Early Life and Adult Intestinal Microbiome of Intra-Uterine Growth Restricted Rat Offspring Exposed to a High Fat and Fructose Diet. Nutrients. 2023 Jan 1
  29. Chernikova DA, Zhao MY, Jacobs JP. Microbiome Therapeutics for Food Allergy. Nutrients. 2022 Dec 3
  30. Kim HN, Kim MJ, Jacobs JP, Yang HJ. Altered Gastric Microbiota and Inflammatory Cytokine Responses in Patients with Helicobacter pylori-Negative Gastric Cancer. Nutrients. 2022 Nov 23
  31. Jacobs JP, Goudarzi M, Lagishetty V, Li D, Mak T, Tong M, Ruegger P, Haritunians T, Landers C, Fleshner P, Vasiliauskas E, Ippoliti A, Melmed G, Shih D, Targan S, Borneman J, Fornace AJ Jr, McGovern DPB, Braun J. Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome. Genome Med. 2022 Aug 15
  32. Sauk JS, Ryu HJ, Labus JS, Khandadash A, Ahdoot AI, Lagishetty V, Katzka W, Wang H, Naliboff B, Jacobs JP, Mayer EA. High Perceived Stress is Associated with Increased Risk of Ulcerative Colitis Clinical Flares. Clin Gastroenterol Hepatol. 2022 Aug 8
  33. Medel-Matus JS, Simpson CA, Ahdoot AI, Shin D, Sankar R, Jacobs JP, Mazarati AM. Modification of post-traumatic epilepsy by fecal microbiota transfer. Epilepsy Behav. 2022 Sep
  34. Bae SS, Dong TS, Wang J, Lagishetty V, Katzka W, Jacobs JP, Charles-Schoeman C. Altered Gut Microbiome in Patients with Dermatomyositis. ACR Open Rheumatol. 2022 May 26
  35. Medel-Matus J, Lagishetty V, Santana-Gomez C, Shin D, Mowrey W, Staba RJ, Galanopoulou AS, Sankar R, *Jacobs JP, *Mazarati AM. Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile. Epilepsia. 2022 Jul *Co-senior authors
  36. Lee SM, Milillo MM, Krause-Sorio B, Siddarth P, Kilpatrick L, Narr KL, Jacobs JP, Lavretsky H. Gut Microbiome Diversity and Abundance Correlate with Gray Matter Volume (GMV) in Older Adults with Depression. Int J Environ Res Public Health. 2022 Feb 19
  37. Mirzayi C, Renson A, STORMS Consortium in alphabetical order (Jacobs JP), Jones HE, Waldron L. Reporting guidelines for human microbiome research: the STORMS checklist. Nat Med. 2021 Nov
  38. Jacobs JP, Gupta A, Bhatt RR, Brawer J, Gao K, Tillisch K, Lagishetty V, Firth R, Gudleski GD, Ellingson BM, Labus JS, Naliboff BD, Lackner JM, Mayer EA. Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement. Microbiome. 2021 Nov 30
  39. Lee SM , Dong TS, Krause-Sorio B, Siddarth P , Milillo MM, Lagishetty V, Datta T, Aguilar-Faustino Y, Jacobs JP, Lavretsky H. The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study. Int Psychogeriatr. 2021 Mar 24
  40. Fox M, Lee SM, Wiley KS, Lagishetty V, Sandman CA, *Jacobs JP, *Glynn LM. Development of the infant gut microbiome predicts temperament across the first year of life. Dev Psychopathol. 2021 Jun 10 *Co-senior authors
  41. Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. The intestinal microbiome predicts weight loss on a calorie-restricted diet and is associated with improved hepatic steatosis. Front Nutr. 2021 Jul 8
  42. Shieh A, Lee SM, Lagishetty V, Gottleib C, Jacobs JP, Adams JS. Pilot trial of cholecalciferol and calcifediol in healthy vitamin D deficient adults: does it change the fecal microbiome? J Clin Endocrinol Metab. 2021 Aug 3
  43. Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 2020 Oct 23
  44. Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot A, Li Z, Pisegna JR, Jacobs JP. A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity. Nutrients. 2020 Oct 21
  45. Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis. Nutrients. 2020 May 13
  46. Dong TS, Katzka W, Lagishetty V, Luu K, Hauer M, Pisegna J, Jacobs JP. A Microbial Signature Identifies Advanced Fibrosis in Patients with Chronic Liver Disease Mainly Due to NAFLD. Sci Rep. 2020 Feb 17
  47. Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka, Rozengurt E, Jacobs JP, Eibl G. Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1
  48. Jacobs JP, Mayer EA. Psychobiotics: Shaping the Mind With Gut Bacteria. Am J Gastroenterol. 2019 Jul; 114(7):1034-1035. [PMID: 31268916]
  49. Dong TS, Jacobs JP. Nonalcoholic fatty liver disease and the gut microbiome: Are bacteria responsible for fatty liver? Exp Biol Med (Maywood). 2019 Apr
  50. Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice. Immunity. 2019 Jan 15
  51. *Jacob N, *Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018 Jul 9 *Co-first authors
  52. Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study. Hepatol Res. 2018 Dec; Epub 2018 Jul 30
  53. *Wang L, *Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR Jr, Pisegna JR, Taché Y. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2017 *Co-first authors
  54. Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DPB, Fornace AJ, Borneman J, Xia L, Braun J. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017 Jan
  55. *Moussaoui N, *Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. Journal of Neurogastroenterology and Motility. 2017 *Co-first authors
  56. Jacobs JP, Goudarzi M, Singh N, Tong M, McHardy IH, Ruegger P, Asadourian M, Moon B, Ayson A, Borneman J, McGovern DPB, Fornace AJ, Braun J, Dubinsky M. A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients. Cellular and Molecular Gastroenterology and Hepatology. 2016 Jul
  57. Jacobs JP, Braun J. Immune and genetic gardening of the intestinal microbiome. FEBS Letters. 2014 Nov