Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

About

Brief Summary

Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.

Study Type

Observational

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

5 Years

Maximum Age

N/A

Inclusion Criteria:

Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
Have a suspected or confirmed diagnosis of:
- Cryoglobulinemic vasculitis (CV)
- Drug-induced vasculitis
- Eosinophilic granulomatosis with polyangiitis (EGPA)
- IgA vasculitis
- Isolated cutaneous vasculitis
- Granulomatosis with polyangiitis (GPA)
- Microscopic polyangiitis (MPA)
- Polyarteritis nodosa (PAN)
- Urticarial vasculitis
Be willing and able to provide written informed consent (or assent for those under

Exclusion Criteria:

You are less than five years old
Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
You have an uncontrolled disease that could prevent you from completing the study procedures
You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study
You are pregnant or nursing
You are not able to provide informed consent

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