Publications

Selected Publications

Link to other NIH Publications(Link is external)

(*) Indicates Corresponding author

Hu, J., Pauer, G.J., Hagstrom, S.A., Bok, D., DeBenedictis, M.J., Bonilha, V., Hollyfield, J.G., and Radu, R.A.*: Evidence of Complement Dysregulation in Outer Retina of Stargardt Disease Donor Eyes. Redox Biology 2020; 37:101787.
PMID: 33214125(Link is external)  PMCID: PMC7767765(Link is external)  DOI: 10.1016/j.redox.2020.101787(Link is external)

Bonilha, V.L., Bell, B.A., Hu, J., Milliner, C., Pauer, G.J., Hagstrom, S.A., Radu, R.A., and Hollyfield, J.G: Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lessions. Invest. Ophthalmol. Vis. Sci. 2020; 5 Jul 1;61(8):15.
PMID: 32658960(Link is external)  PMCID: PMC7425718(Link is external)  DOI: 10.1167/iovs.61.8.15(Link is external)

Fang, Y., Tschulakow, A., Taubitz, T., Illing, B., Biesemeier, A., Julien-Schraermeyer, S., Jiang, Z., Radu, R.A., and Schraermeyer U: Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in Stargardt disease mouse model.  FASEB J. 2020 Mar;34(3):3693-3714. Epub 2020 Jan 27. 
PMID: 31989709(Link is external)   DOI: 10.1096/fj.201901784RR.(Link is external)

Morshedian, A., Kaylor, J.J., Ng, S.Y., Tsan, A., Frederiksen, R., Xu, T., Yuan, L., Sampath, A.P., Radu, R.A., Fain, G.L., Travis, G.H: Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Müller glial cells.  Neuron 2019; 102(6): 1172-1180
PMID: 31056353(Link is external)  PMCID: PMC6586478(Link is external)  DOI: 10.1016/j.neuron.2019.04.004(Link is external)

Lenis, T.L., Hu, J., Ng, S.Y., Jiang, Z., Sarfare, S., Lloyd, M.B., Esposito, N., Samuel, W., Jaworski, C., Bok, D., Finnemann, S., Radeke, M., Redmond, T.M., Travis, G.H., and Radu, R.A.*: Expression of ABCA4 in Retinal Pigment Epithelium and its implications for Stargardt disease. – Proc. Natl. Acad. Sci. USA. 2018; 115(47):E11120-E11127
PMID: 30397118(Link is external)  PMCID: PMC6255167(Link is external)   DOI: 10.1073/pnas.1802519115(Link is external)

McClements, M.E., Barnard, A.R., Singh, M.S., Charbel Issa, P., Jiang, Z., Radu, R.A., and MacLaren, R.E: An AAV dual vector strategy ameliorates the Stargardt phenotype in adult ABCA4-/- mice.  Human gene therapy. 2018; 30(5): 590-600
PMID: 30381971(Link is external)  PMCID: PMC6909730(Link is external)  DOI: 10.1089/hum.2018.156(Link is external)

Cook, J.D., Ng, S.Y., Lloyd, M., Eddington, S., Sun H., Nathans, J., Bok, D., Radu, R.A., and Travis, G.H:  Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J. Biol. Chem. 2018; 292(52):21407-21416
PMID: 29109151(Link is external)  PMCID: PMC5766940(Link is external)  DOI: 10.1074/jbc.M117.812701(Link is external)

Lenis, T.L., Sarfare, S., Jiang, Z., Lloyd, M.B., Bok, D., and Radu, R.A.*: Complement Modulation in the Retinal Pigment Epithelium Rescues Photoreceptor Degeneration in a Mouse Model of Stargardt Disease.  Proc. Natl. Acad. Sci. USA. 2017; 114(15):3987-3992 PMID: 28348233(Link is external)  PMCID: PMC5393232(Link is external)   DOI: 10.1073/pnas.1620299114(Link is external)

Kaylor, J.J., Radu, R.A., Bischoff, N., Makshanoff, J., Hu, J., Lloyd, M., Eddington, S., Bianconi, T., Bok, D., Travis, G.H: Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. PLoS One. 2015; 10(5):1-14 PMID: 25974161(Link is external)  PMCID: PMC4431840(Link is external)   DOI: 10.1371/journal.pone.0125921(Link is external)

Smit-McBride, Z., Oltjen, S.L., Radu, R.A., Estep, J., Nguyen, A.T., Gong, Q., and Hjelmeland, L.M: Localization of complement factor H gene expression and protein distribution in the mouse outer retina. Molec. Vis. 2015; 21:110-123
PMID: 25684976(Link is external)  PMCID: PMC4323684(Link is external)

Radu, R.A.*, Hu, J., Jiang, Z., and Bok, D: Bisretinoid-mediated Complement Activation on Retinal Pigment Epithelial Cells is Dependent on Complement Factor H Haplotype. J. Biol. Chem. 2014; 289: 9113-9120
PMID: 21464132(Link is external)  PMCID: PMC3099675(Link is external)   DOI: 10.1074/jbc.M110.191866(Link is external)

Charbel Issa, P., Barnard, R.A., Singh, M., Carter, E., Jiang, Z., Radu, R.A., Schraermeyer, U., and MacLaren, R.A: Fundus Autofluorescence in the Abca4-/- Mouse Model of Stargardt Disease - Correlation with Accumulation of A2E, Retinal Function and Histology. Invest. Ophthalmol. Vis. Sci. 2013; 54(8):5602-12
PMID: 23761084(Link is external)  PMCID: PMC3747716(Link is external)  DOI: 10.1167/iovs.13-11688(Link is external)

Mullins, R.F., Kuehn, M.H., Radu, R.A., Enriquez, S., East, J.S., Schindler, E.I., Travis, G.H., Stone, E.M: Autosomal recessive pigmentosa due to ABCA4 mutations: Clinical, pathological and molecular characterization. Invest. Ophthalmol. Vis. Sci. 2012; 53(4):1883-94
PMID: 22395892(Link is external) PMCID: PMC3995570(Link is external)   DOI: 10.1167/iovs.12-9477(Link is external)

Radu, R.A.*, Hu, J., Yuan, Q., Welch, D.L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G.H., and Bok, D: Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration.  J. Biol. Chem. 2011; 286(21): 18593-18601
PMID: 21464132(Link is external)  PMCID: PMC3099675(Link is external)  DOI: 10.1074/jbc.M110.191866(Link is external)

Radu, R.A., Yuan, Q., Hu, J., Peng, J.H., Lloyd, M., Nusinowitz, S. Bok, D., Travis, G.H: Vitamin A Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for ABCA4-mediated Retinal Dystrophies Following Vitamin A Supplementation. Invest. Ophthalmol. Vis. Sci. 2008; 49(9), 3821-3829
PMID: 18515570(Link is external)  PMCID: PMC2851626(Link is external)  DOI: 10.1167/iovs.07-1470(Link is external)

Radu, R.A., Hu, J., Peng, J.H., Bok, D., Mata, N.L., Travis, G.H: Retinal Pigment Epithelium-retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of all-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells. J. Biol. Chem. 2008; 283(28), 19730-19730
PMID: 18474598(Link is external)  PMCID: PMC2443657(Link is external)   DOI: 10.1074/jbc.M801288200(Link is external)

Bakall, B., Radu, R.A., Stanton, J.B., Burke, J.M., McKay, B.S., Wadelius, C., Mullins, R.F., Stone, E.M., Travis, G.H., Marmorstein, A.D: Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2).  Exp. Eye Res. 2007; 85, 34-43
PMID: 17477921(Link is external)  DOI: 10.1016/j.exer.2007.02.018(Link is external)

Radu, R.A., Han, Y., Bui, T.V., Nusinowitz, S., Bok, D., Lichter, J., Widder, K., Travis, G.H., Mata, N.L. Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-based Retinal Diseases.  Invest. Ophthalmol. Vis. Sci. 2005; 46, 4393-4401.
PMID: 16303925  DOI: 10.1167/iovs.05-0820(Link is external)

Mata, N.L., Ruiz, A., Radu, R.A., Bui, T.V., Travis, G.H. Chicken Retinas Contain a Retinoid Isomerase Activity that Catalyzes the Direct Conversion of all-trans-retinol to 11-cis-retinol.  Biochemistry. 2005; 44, 11715-11721 PMID: 16128572.
PMID: 16128572 PMCID: PMC2851629(Link is external)                   DOI: 10.1021/bi050942m(Link is external)

Radu, R.A., Mata, N.L., Bagla, A., and Travis, G.H. Light Exposure Stimulates Formation of A2E Oxirane in a Mouse Model of Stargardt's Macular Degeneration.  Proc. Natl. Acad. Sci. USA. 2004; 101, 5928-5933; PMCID:PMC395900.
PMID: 15067110         PMCID: PMC395900(Link is external)              DOI: 10.1073/pnas.0308302101(Link is external)

Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., and Travis, G.H. Treatment with Isotretinoin Inhibits Lipofuscin Accumulation in a Mouse Model of Recessive Stargardt's Macular Degeneration.  Proc. Natl. Acad. Sci. USA. 2003; 100, 4742-4747
PMID: 12671074         PMCID: PMC153626(Link is external)              DOI: 10.1073/pnas.0737855100(Link is external)

Mata, N.L., Radu, R.A., Clemmons, R.S., and Travis, G.H. Isomerization and Oxidation of Vitamin A in Cone-dominant retinas: Evidence for a New Pathway that Mediates Regeneration of Visual Pigments in Daylight.  Neuron. 2002; 36, 69-80
PMID: 12367507         PMCID: PMC2851622(Link is external)            DOI: 10.1016/s0896-6273(02)00912-1(Link is external)