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Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

About

Brief Summary

A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.

Primary Purpose

Basic science

Study Type

Interventional

Phase

N/A

Eligibility

Gender

All

Healthy Volunteers

Minimum Age

N/A

Maximum Age

36 Weeks

Inclusion Criteria:

born between 25 0/7 and 29 6/7 weeks of gestation
less than 48 hours of age at first lipid dose (The cohort is defined by gestational age rather than birth weight to avoid an over-represented sample of growth-restricted infants in birth weight defined cohorts.)

Exclusion Criteria:

serious congenital anomalies
conditions at birth that will require surgery prior to discharge
imminent death such that withdrawal of intensive care support is anticipated within the first 72 hours after birth

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