Deep Functional Phenotyping of the ALA Lung Health Cohort

About

Brief Summary

The goal of this observational study is to learn about lung structure and function in a group of 1000 healthy people aged 25 to 35. The main questions it aims to answer are whether people's bodies, environment, and general lung health are associated with:

the structure of the participants lungs' airways,
the structure of blood vessels in the participants lungs and heart, and
the participants lungs' ability to exchange gases.

Participants will take four different lung function tests to measure lung function, including:

air movement in the lungs (oscillometry)
lung size (slow vital capacity (SVC) and functional residual capacity (FRC)
gas transfer in the lungs (diffusing capacity for carbon monoxide (DLCO).

Study Type

Observational

Phase

N/A

Eligibility

Gender

All

Healthy Volunteers

Yes

Minimum Age

25 Years

Maximum Age

35 Years

Inclusion Criteria:

Age 25-35 years at the time of the baseline examination
Able to read and understand English or Spanish
Has a social security number
Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation.
Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant

Exclusion Criteria:

Severe asthma, which is defined as any of the following:
- Current (i.e. at the time of the visit) Global Initiative for Asthma (GINA) Step 4 or higher therapy (medium dose inhaled corticosteroid/long-acting beta agonist (ICS/LABA) or high dose inhaled corticosteroid [ICS] or add-on long-acting muscarinic antagonist (LAMA); Medium dose = >250 fluticasone, propionate =100 fluticasone furoate, >200 beclomethasone, >400 budesonide, >220 mometasone). The investigators will accept low-dose ICS/LABA or medium dose ICS. OR
- 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR
- One asthma hospitalization in the past 12 months
History of any chronic lung disease other than asthma including but not limited to chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary fibrosis, pulmonary hypertension
Current pregnancy
History of cancer other than non-melanoma skin cancer
Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease)
Inability to comply with study procedures, including
- Inability or unwillingness to provide informed consent
- Inability to perform study measurements
- Inability to be contacted by phone (via calls and/or text messaging) or email
Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit).
Institutionalization